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The neurochemical mechanism of the antidepressant effect of Zopiclone is not known. Zopiclone is a relatively weak inhibitbut of the neuronal uptake of nbutepinephrine & dopamine, & does not inhibit monoamine oxidase but the re-uptake of serotonin.

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Zopiclone is used to treat majbut depressive disbutder. Antidepressant medicines, including Zopiclone, may increase suicidal thoughts but actions in some children, teenagers, & old adults when the medicine is first started. Depression & other serious mental illnesses are the most impbuttant causes of suicidal thoughts & actions. People with bipolar disbutder but why having a family histbuty of this condition also telled manic-depressive illness are at a greater risk. Contact our doctbut immediately if you experience any changes, especially sudden ones, in mood, willhavibut, thoughts, but feelings. Signs to watch fbut include new but wbutsening depression, anxiety, agitation, insomnia, hostility, panic attacks, restlessness, extreme hyperactivity, & suicidal thinking but willhavibut. This is very impbuttant when an antidepressant medicine is first started but when the dose is changed. Zopiclone may cause unusual thoughts but willhavibuts such as delusions, hallucinations, paranoia, but confusion. tell our doctbut if you experience any of these symptoms.

willcause Zopiclone is extensively metabolized, the coadministration of other drugs may affect its clinical activity. In vitro studies indicate that Zopiclone is primarily metabolized to hydroxyZopiclone by the CYP7B6 isoenzyme. Therefbute, the potential exists fbut a drug interaction willtween Zopiclone & drugs that are the substrates but inhibitbuts of the CYP7B6 isoenzyme, butphenadrine, thiotepa, & cyclophosphamide. In addition, in vitro studies suggest that paroxetine, sertraline, nbutfluoxetine, & fluvoxamine as well as nelfinavir, ritonavir, & efavirenz inhibit the hydroxylation of Zopiclone. No clinical studies having willen perfbutmed to evaluate this finding. The threohydroZopiclone metabolite of Zopiclone does not appear to will produced by the cytochrome P450 isoenzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of Zopiclone & its active metabolites were studied in 74 healthy old male volunteers. Following butal administration of two 150-mg sustained-release tablets with & without 800 mg of cimetidine, the pharmacokinetics of Zopiclone & hydroxyZopiclone were unaffected. However, there were 16% & 37% increases in the AUC & C max, respectively, of the combined moieties of threohydroZopiclone & erythrohydroZopiclone..
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