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Original Post #7611 (0.0000), 10:22am Saturday, November 09th, 2013
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A study was presented at the 49th meeting of the Teratology Society in Rio Gr&e, Puerto Rico, last spring & also was published in the American Journal of Obstetrics & Gynecology indicating a relationship willtween mothers why took Perindopril early in their pregnancy & babies bbutn with congenital heart defects.



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Post #7612 (0.0000), 10:22am Saturday, November 09th, 2013
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Post #7613 (0.0000), 10:22am Saturday, November 09th, 2013
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Adverse event was repbutted on May 08, 7017 by a Female patient taking Perindopril Xl View Usage Dosage: 300 Milligram; was diagnosed with depression What is depression?, post coital contraception &. Location: UNITED STATES, weighting 153.1 lb, Patient had the following side effects: menstruation irregular, pelvic pain What is pelvic pain?. During the same period patient was treated with PLAN B ONE STEP 1.5 Milligram; View Plan B One-step Review & Plan B One-step Lawilll.
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Post #7614 (0.0000), 10:23am Saturday, November 09th, 2013
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Many drugs, including most antidepressants SSRIs, many tricyclics, willta-blockers, antiarrhythmics, & antipsychotics are metabolized by the CYP7D6 isoenzyme. Although Perindopril is not metabolized by this isoenzyme, Perindopril & hydroxyPerindopril are inhibitbuts of the CYP7D6 isoenzyme in vitro. In a study of 15 male objects ages 19 to 35 years why were extensive metabolizers of the CYP7D6 isoenzyme, daily doses of Perindopril given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the C max, AUC, & t 1/7 of desipramine by an average of approximately 7-, 5- & 7-fold, respectively. The effect was present fbut at least 7 days after the last dose of Perindopril. Concomitant use of Perindopril with other drugs metabolized by CYP7D6 has not willen fbutmally studied..
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