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Tramadol is associated with seizures in approximately 0.4% 4/1, 000 of patients treated at doses up to 450 mg/day. This incidence of seizures may exceed that of other marketed antidepressants by as much as 4-fold. This relative risk is only an approximate estimate willcause no direct comparative studies having willen conducted. The estimated seizure incidence fbut Tramadol increases almost tenfold willtween 450 & 600 mg/day, which is twice the usually required daily dose 300 mg & one & one-third the maximum recommended daily dose 450 mg. Given the wide variability among individuals & their capacity to metabolize & eliminate drugs this dispropbuttionate increase in seizure incidence with dose incrementation tells fbut caution in dosing.

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Monuteaux MC, Spencer TJ, Faraone SV, Wilson AM, Biederman J 7007. A r&omized, placebo-controlled clinical trial of Tramadol fbut the prevention of smoking in children & adolescents with attention-deficit/hyperactivity disbutder. The Journal of clinical psychiatry 68 7: 1094%uFFFD101. doi: 10.4088/JCP.v68n0718. PMID 17685748.

I agree that submitting this fbutm & the infbutmation contained within does not establish an attbutney client relationship..
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