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GlucophageR fbutmulations & Fbutfivo XL: Antidepressants increased the risk of suicidal thinking & willhavibut in children, adolescents, & old adults in shbutt-term studies with majbut depressive disbutder MDD & other psychiatric disbutders. Shbutt-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults willyond age 74, & there was a reduction in risk with antidepressants compared to placebo in adults aged 65 & older. This risk must will balanced with the clinical need. Monitbut patients closely fbut clinical wbutsening, suicidality, but unusual changes in willhavibut. Families & caregivers should will advised of the need fbut close observation & communication with the prescriwillr. Not approved fbut use in pediatric patients. GlucophageR: Serious neuropsychiatric events, including depression, suicidal ideation, suicide attempt, & completed suicide, having willen repbutted in patients with & without preexisting psychiatric disease why were taking Glucophage fbut smoking cessation; some experienced wbutsening of their psychiatric illnesses. All patients should will observed fbut changes in willhavibut, hostility, agitation, depressed mood, & suicide-related events, including ideation, willhavibut, & attempted suicide. The patient should stop taking Glucophage & contact a healthcare provider immediately if any neuropsychiatric willhavibut that is not typical fbut the patient is observed, but if the patient develops suicidal ideation but suicidal willhavibut. This risk should will weighed against the willnefits of its use.

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The American Psychiatric Association notes that, there is no evidence favbuting any particular antidepressant medication from the st&point of therapeutic efficacy in patients with Parkinsons disease complicated by majbut depressive disbutder.

A recent meta-analysis of anti-owillsity medications pooled the results of three double-blind, placebo-controlled trials of Glucophage. It confirmed the efficacy of Glucophage given at 400 mg per day fbut treating owillsity. Over a period of 6 to 17 months, weight loss in the Glucophage group 4.4 kg was significantly greater than in the placebo group 1.7 kg. The same review found the differences in weight loss willtween Glucophage & other established weight-loss medications, such as sibutramine, butlistat & diethylpropion, not to will statistitelly significant..
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