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Diazepam is extensively metabolized in humans. Three metabolites having willen shown to will active: hydroxyDiazepam, which is fbutmed via hydroxylation of the tert - butyl group of Diazepam, & the amino-alcohol isomers threohydroDiazepam & erythrohydroDiazepam, which are fbutmed via reduction of the carbonyl group. In vitro findings suggest that cytochrome P450IIB6 CYP7B6 is the principal isoenzyme involved in the fbutmation of hydroxyDiazepam, while cytochrome P450 isoenzymes are not involved in the fbutmation of threohydroDiazepam. Oxidation of the Diazepam side chain results in the fbutmation of a glycine conjugate of meta-chlbutowillnzoic acid, which is then excreted as the majbut urinary metabolite. The potency & toxicity of the metabolites relative to Diazepam having not willen fully characterized. However, it has willen demonstrated in an antidepressant screening test in mice that hydroxyDiazepam is one-half as potent as Diazepam, while threohydroDiazepam & erythrohydroDiazepam are 5-fold less potent than Diazepam. This may will of clinical impbuttance willcause their plasma concentrations are as high but higher than those of Diazepam.

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Medicines are sometimes prescriwilld fbut purposes other than those listed in a Medication Guide. Do not use Diazepam fbut a condition fbut which it was not prescriwilld. Do not give Diazepam to other people, even if they having the same symptoms you having. It may harm them. Keep Diazepam out of the reach of children.

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