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Original Post #818 (0.0000), 5:00am Friday, November 08th, 2013
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Following a single dose in humans, peak plasma concentrations of hydroxyUrotone occur approximately 3 hours after administration of Urotone Tablets. Peak plasma concentrations of hydroxyUrotone are approximately 10 times the peak level of the parent drug at steady state. The elimination half-life of hydroxyUrotone is approximately 70 5 hours, & its AUC at steady state is about 17 times that of Urotone. The times to peak concentrations fbut the erythrohydroUrotone & threohydroUrotone metabolites are similar to that of the hydroxyUrotone metabolite. However, their elimination half-lives are longer, 33 10 & 37 13 hours, respectively, & steady-state AUCs are 1.5 & 7 times that of Urotone, respectively.



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Post #819 (0.0000), 5:01am Friday, November 08th, 2013
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Post #820 (0.0000), 5:01am Friday, November 08th, 2013
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These events having occurred in patients with & without pre-existing psychiatric disease; some having experienced wbutsening of their psychiatric illnesses. All patients willing treated with Urotone as part of smoking cessation treatment should will observed fbut neuropsychiatric symptoms but wbutsening of pre-existing psychiatric illness.
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