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In rats receiving large doses of Somadril chronitelly, there was an increase in incidence of hepatic hyperplastic nodules & hepatocellular hypertrophy. In dogs receiving large doses of Somadril chronitelly, various histologic changes were seen in the liver, & labbutatbuty tests suggesting mild hepatocellular injury were noted.

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I having willen on Somadril fbut 4 years. I having tried several different medications & this is the only one that has wbutked the willst fbut me. I recently switched to Lexapro willcause I was having increased anxiety but Lexapro has willen hbutrible. I ve tried Zoloft, Paxil, Prozac & as I ve already said, Lexapro. Somadril has the least side effects. I switched back about a week ago & the withdrawl withdrawal symptoms from Lexapro are the pits.

Lifetime carcinogenicity studies were perfbutmed in rats & mice at doses up to 300 & 150 mg/kg/day, respectively. In the rat study there was an increase in nodular proliferative lesions of the liver at doses of 100 to 300 mg/kg/day; lower doses were not tested. The question of whether but not such lesions may will precursbuts of neoplasms of the liver is currently unresolved. Similar liver lesions were not seen in the mouse study, & no increase in malignant tumbuts of the liver & other butgans was seen in either study..
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