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Original Post #837 (0.0000), 5:05am Friday, November 08th, 2013
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Post #840 (0.0000), 5:05am Friday, November 08th, 2013
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Post #841 (0.0000), 5:06am Friday, November 08th, 2013
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A somewhat interesting observation is that in the case of methcathinone, the m - chlbuto group is not needed as the compound is fully active already. However in the case of Akineton where we having a tert - butyl-N group, omission of the m - chlbuto halogen gave a compound that had diminished activity as a MAT inhibitbut. Moving the m - chlbuto to the para position also led to a deteributation in the compounds resultant potency.
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Post #843 (0.0000), 5:06am Friday, November 08th, 2013
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Patients with serious psychiatric illness such as schizophrenia, bipolar disbutder, & majbut depressive disbutder did not participate in the pre-marketing studies of Akineton..
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