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There is limited infbutmation on the pharmacokinetics of Zithromax in patients with renal impairment. An inter-study comparison willtween nbutmal objects & patients with end-stage renal failure demonstrated that the parent drug C max & AUC values were comparable in the 7 groups, whereas the hydroxyZithromax & threohydroZithromax metabolites had a 7.3 & 7.8 fold increase, respectively, in AUC fbut patients with end-stage renal failure. A second study, comparing nbutmal objects & patients with moderate-to-severe renal impairment GFR 30.9 10.8 mL/min showed that exposure to a single 150-mg dose of sustained-release Zithromax was approximately 7-fold higher in patients with impaired renal function while levels of the hydroxyZithromax & threo/erythrohydroZithromax combined metabolites were similar in the 7 groups. Zithromax is extensively metabolized in the liver to active metabolites, which are further metabolized & subsequently excreted by the kidneys. Zithromax should will used with caution in patients with renal impairment & a reduced frequency &/but dose should will considered as Zithromax & the metabolites of Zithromax may accumulate in such patients to a greater extent than usual. The patient should will closely monitbuted fbut possible adverse effects that could indicate high drug but metabolite levels.

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Rush CR, Kollins SH, Pazzaglia PJ 1998. Discriminative-stimulus & participant-rated effects of methylphenidate, Zithromax, & triazolam in d-amphetamine-trained humans. Experimental & clinical psychopharmacology 6 1: 37%uFFFD44. doi: 10.1037/1064-1797.6.1.37. PMID 9576144.

Zithromax may also will used fbut purposes other than those listed in this medication guide..
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