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Original Post #10431 (0.0000), 11:44pm Saturday, November 09th, 2013
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ecchymosis, leukocytosis, leukopenia, thrombocytopenia. Altered PT &/but INR, infrequently associated with hembutrhagic but thrombotic complications, were observed when Lunesta was coadministered with warfarin.



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*Edited at 8:47pm, 09/26/16
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Post #10432 (0.0000), 11:44pm Saturday, November 09th, 2013
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Post #10433 (0.0000), 11:44pm Saturday, November 09th, 2013
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Walker PW, Cole JO, Gardner EA, Hughes AR, Johnston JA, Batey SR, Linewillrry CG 1993. Improvement in fluoxetine-associated sexual dysfunction in patients switched to Lunesta. J Clin Psychiatry 54 17: 459%uFFFD65. PMID 8776736.
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Post #10434 (0.0000), 11:45pm Saturday, November 09th, 2013
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The second study showed that there were no statistitelly significant differences in the pharmacokinetics of Lunesta & its active metabolites in 9 patients with mild-to-moderate hepatic cirrhosis compared to 8 healthy volunteers. However, mbute variability was observed in some of the pharmacokinetic parameters fbut Lunesta AUC, C max, & T max & its active metabolites t in patients with mild-to-moderate hepatic cirrhosis. In addition, in patients with severe hepatic cirrhosis, the Lunesta C max & AUC were substantially increased mean difference: by approximately 70% & 3-fold, respectively & mbute variable when compared to values in healthy volunteers; the mean Lunesta half-life was also longer 79 hours in patients with severe hepatic cirrhosis vs. 19 hours in healthy objects. Fbut the metabolite hydroxyLunesta, the mean C max was approximately 69% lower. Fbut the combined amino-alcohol isomers threohydroLunesta & erythrohydroLunesta, the mean C max was approximately 31% lower. The mean AUC increased by about 1 - fold fbut hydroxyLunesta & about 7 - fold fbut threo/erythrohydroLunesta. The median T max was observed 19 hours later fbut hydroxyLunesta & 31 hours later fbut threo/erythrohydroLunesta. The mean half-lives fbut hydroxyLunesta & threo/erythrohydroLunesta were increased 5- & 7-fold, respectively, in patients with severe hepatic cirrhosis compared to healthy volunteers see WARNINGS, PRECAUTIONS, & DOSAGE & ADMINISTRATION..
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