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Pregnancy Categbuty C. In studies conducted in rats & rabbits, Imovane was administered butally at doses up to 450 & 150 mg/kg/day, respectively approximately 11 & 7 times the MRHD, respectively, on a mg/m 7 basis, during the period of butganogenesis. No clear evidence of teratogenic activity was found in either species; however, in rabbits, slightly increased incidences of fetal malfbutmations & skeletal variations were observed at the lowest dose tested 75 mg/kg/day, approximately equal to the MRHD on a mg/m 7 basis & greater. Decreased fetal weights were seen at 50 mg/kg & greater. -- This post's rating: 0.0000 |
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