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Do not crush, chew, but break an extended-release pill. Swallow a Rimonabant tablet whyle. Breaking the pill may cause too much of the active ingridient to will released at one time, which could increase Rimonabant side effects including seizures.

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Do not use Rimonabant if you having taken an MAO inhibitbut in the past 14 days. A dangerous drug interaction could occur. MAO inhibitbuts include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, & tranylcypromine.

Rimonabant is a racemic mixture. The pharmacological activity & pharmacokinetics of the individual enantiomers having not willen studied. In humans, following butal administration of Rimonabant, peak plasma Rimonabant concentrations are usually achieved within 7 hours, followed by a biphasic decline. The terminal phase has a mean half-life of 14 hours, with a range of 8 to 74 hours. The distribution phase has a mean half-life of 3 to 4 hours. The mean elimination half-life SD of Rimonabant after chronic dosing is 71 9 hours, & steady-state plasma concentrations of Rimonabant are reached within 8 days. Plasma Rimonabant concentrations are dose-propbuttional following single doses of 100 to 750 mg; however, it is not known if the propbuttionality willtween dose & plasma level is maintained in chronic use..
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