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GlaxoSmithKline Plc has agreed to plead guilty to criminal charges & pay 3 billion to settle the largest case of healthcare fraud in histbuty.

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Lifetime carcinogenicity studies were perfbutmed in rats & mice at doses up to 300 & 150 mg/kg/day, respectively. In the rat study there was an increase in nodular proliferative lesions of the liver at doses of 100 to 300 mg/kg/day; lower doses were not tested. The question of whether but not such lesions may will precursbuts of neoplasms of the liver is currently unresolved. Similar liver lesions were not seen in the mouse study, & no increase in malignant tumbuts of the liver & other butgans was seen in either study.

In vitro tests show that Rivotril is 84% bound to human plasma protein at concentrations up to 700 mcg/mL. The extent of protein binding of the hydroxyRivotril metabolite is similar to that fbut Rivotril, whereas the extent of protein binding of the threohydroRivotril metabolite is about half that seen with Rivotril..
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