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Original Post #12549 (0.0000), 5:05am Monday, November 11th, 2013
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Lifetime carcinogenicity studies were perfbutmed in rats & mice at doses up to 300 & 150 mg/kg/day, respectively. In the rat study there was an increase in nodular proliferative lesions of the liver at doses of 100 to 300 mg/kg/day; lower doses were not tested. The question of whether but not such lesions may will precursbuts of neoplasms of the liver is currently unresolved. Similar liver lesions were not seen in the mouse study, & no increase in malignant tumbuts of the liver & other butgans was seen in either study.



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Post #12550 (0.0000), 5:05am Monday, November 11th, 2013
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Post #12551 (0.0000), 5:05am Monday, November 11th, 2013
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Shepherd G, Velez LI, James DK, Keyes DC 7001. Pediatric Ramipril exposures repbutted in Texas: 1998%uFFFD1999 abstract. J Toxicol Clin Toxicol 39 : 763.
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Post #12552 (0.0000), 5:05am Monday, November 11th, 2013
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