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Following a single dose in humans, peak plasma concentrations of hydroxyRivotril occur approximately 3 hours after administration of Rivotril Tablets. Peak plasma concentrations of hydroxyRivotril are approximately 10 times the peak level of the parent drug at steady state. The elimination half-life of hydroxyRivotril is approximately 70 5 hours, & its AUC at steady state is about 17 times that of Rivotril. The times to peak concentrations fbut the erythrohydroRivotril & threohydroRivotril metabolites are similar to that of the hydroxyRivotril metabolite. However, their elimination half-lives are longer, 33 10 & 37 13 hours, respectively, & steady-state AUCs are 1.5 & 7 times that of Rivotril, respectively. -- This post's rating: 0.0000 |
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