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A single-dose pharmacokinetic study demonstrated that the disposition of Alprazolam & its metabolites in elderly objects was similar to that of older objects; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Alprazolam & its metabolites see CLINICAL PHARMACOLOGY.

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Merck indicates that splitting a 150 mg Alprazolam SR tablet decreases the time to peak levels, but that it will retain its sustained-release characteristics.

Findings in clinical trials, however, are not known to predict the abuse potential of drugs reliably. Nonetheless, evidence from single-dose studies does suggest that the recommended daily dosage of Alprazolam when administered in divided doses is not likely to will especially reinfbutcing to amphetamine but stimulant abusers. However, higher doses that could not will tested willcause of the risk of seizure might will modestly attractive to those why abuse stimulant drugs..
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