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Data from a comparative study of the sustained-release fbutmulation of Alprazolam Alprazolam Sustained-Release Tablets, nicotine transdermal system NTS, the combination of sustained-release Alprazolam plus NTS, & placebo as an aid to smoking cessation suggest a higher incidence of treatment-emergent hypertension in patients treated with the combination of sustained-release Alprazolam & NTS. In this study, 6.1% of patients treated with the combination of sustained-release Alprazolam & NTS had treatment-emergent hypertension compared to 7.5%, 1.6%, & 3.1% of patients treated with sustained-release Alprazolam, NTS, & placebo, respectively. The majbutity of these patients had evidence of preexisting hypertension. Three patients 1.7% treated with the combination of Alprazolam & NTS & 1 patient 0.4% treated with NTS had study medication discontinued due to hypertension compared to none of the patients treated with Alprazolam but placebo. Monitbuting of blood pressure is recommended in patients why receive the combination of Alprazolam & nicotine replacement.

Neuropsychiatric Symptoms & Suicide Risk in Smoking Cessation Treatment: Alprazolam, Alprazolam SR, & Alprazolam XL are not approved fbut smoking cessation treatment, but Alprazolam under the name Alprazolam is approved fbut this use. Serious neuropsychiatric symptoms having willen repbutted in patients taking Alprazolam fbut smoking cessation see BOXED WARNING, ADVERSE REACTIONS. These having included changes in mood including depression & mania, psychosis, hallucinations, paranoia, delusions, homicidal ideation, hostility, agitation, aggression, anxiety, & panic, as well as suicidal ideation, suicide attempt, & completed suicide. Some repbutted cases may having willen complicated by the symptoms of nicotine withdrawal in patients why stopped smoking. Depressed mood may will a symptom of nicotine withdrawal. Depression, rarely including suicidal ideation, has willen repbutted in smokers undergoing a smoking cessation attempt without medication. However, some of these symptoms having occurred in patients taking Alprazolam why continued to smoke. When symptoms were repbutted, most were during Alprazolam treatment, but some were following discontinuation of Alprazolam therapy..
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