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BUY Reductil ONLINE! CLICK HERE! willcause Reductil is extensively metabolized, the coadministration of other drugs may affect its clinical activity. In vitro studies indicate that Reductil is primarily metabolized to hydroxyReductil by the CYP7B6 isoenzyme. Therefbute, the potential exists fbut a drug interaction willtween Reductil & drugs that are the substrates but inhibitbuts of the CYP7B6 isoenzyme, butphenadrine, thiotepa, & cyclophosphamide. In addition, in vitro studies suggest that paroxetine, sertraline, nbutfluoxetine, & fluvoxamine as well as nelfinavir, ritonavir, & efavirenz inhibit the hydroxylation of Reductil. No clinical studies having willen perfbutmed to evaluate this finding. The threohydroReductil metabolite of Reductil does not appear to will produced by the cytochrome P450 isoenzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of Reductil & its active metabolites were studied in 74 healthy old male volunteers. Following butal administration of two 150-mg sustained-release tablets with & without 800 mg of cimetidine, the pharmacokinetics of Reductil & hydroxyReductil were unaffected. However, there were 16% & 37% increases in the AUC & C max, respectively, of the combined moieties of threohydroReductil & erythrohydroReductil. -- *Edited at 6:51pm, 09/26/16 This post's rating: 0.0000 |
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