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0 mg/kg/day, respectively, after normalization for total body surface area. In severe nodular acne, many red, swollen, tender lumps form in the skin.understand that isotretinoin is a medicine used to treat severe nodular acne that cannot be cleared up by any other acne treatments, including antibiotics. Roche Holding AG, the manufacture, has pulled Accutane off the market in 11 other countries and law suits are still pending settlement.Accutane is being pulled off the U. In studies of 66 men, 30 of whom were patients with nodular acne under treatment with oral isotretinoin, no significant changes were noted in the count or motility of spermatozoa in the ejaculate. market due to the high volume of Accutane lawsuits the manufacturer has lost. In dogs, testicular atrophy was noted after treatment with oral isotretinoin for approximately 30 weeks at dosages of 20 or 60 mg/kg/day 10 or 30 times the recommended clinical dose of 1. Juries have awarded approximately $33 million in damages so far. In a study of 50 men ages 17 to 32 years receiving Accutane isotretinoin therapy for nodular acne, no significant effects were seen on ejaculate volume, sperm count, total sperm motility, morphology or seminal plasma fructose. Roaccutane 50 mg.. In general, there was microscopic evidence for appreciable depression of spermatogenesis but some sperm were observed in all testes examined and in no instance were completely atrophic tubules seen. S. . If untreated, severe nodular acne can lead to permanent scars.

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