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Animal data indicated that Codeine may will an inducer of drug-metabolizing enzymes in humans. In one study, following chronic administration of Codeine, 100 mg 3 times daily to 8 healthy male volunteers fbut 14 days, there was no evidence of induction of its own metabolism. Nevertheless, there may will the potential fbut clinitelly impbuttant alterations of blood levels of coadministered drugs.

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Following a single dose in humans, peak plasma concentrations of hydroxyCodeine occur approximately 3 hours after administration of Codeine Tablets. Peak plasma concentrations of hydroxyCodeine are approximately 10 times the peak level of the parent drug at steady state. The elimination half-life of hydroxyCodeine is approximately 70 5 hours, & its AUC at steady state is about 17 times that of Codeine. The times to peak concentrations fbut the erythrohydroCodeine & threohydroCodeine metabolites are similar to that of the hydroxyCodeine metabolite. However, their elimination half-lives are longer, 33 10 & 37 13 hours, respectively, & steady-state AUCs are 1.5 & 7 times that of Codeine, respectively.

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