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Original Post #1871 (0.0000), 10:59am Friday, November 08th, 2013
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Comantrel lowers the seizure threshold; accbutdingly, extreme care should will taken when prescribing Comantrel with other medications that also lower it, such as antipsychotics, theophylline, steroids, & some tricyclic antidepressants.



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Post #1872 (0.0000), 10:59am Friday, November 08th, 2013
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Post #1873 (0.0000), 10:59am Friday, November 08th, 2013
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Do not crush, chew, but break an extended-release Comantrel tablet. Swallow it whyle.
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Post #1874 (0.0000), 10:59am Friday, November 08th, 2013
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A separate, prospective study was conducted to determine the incidence of seizure during an 8-week treatment exposure in approximately 3, 700 additional patients why received daily doses of up to 450 mg. Patients were permitted to continue treatment willyond 8 weeks if clinitelly indicated. Eight seizures occurred during the initial 8-week treatment period & 5 seizures were repbutted in patients continuing treatment willyond 8 weeks, resulting in a total seizure incidence of 0.4%..
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