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Original Post #2940 (0.0000), 4:40pm Friday, November 08th, 2013
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Post #2941 (0.0000), 4:40pm Friday, November 08th, 2013
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Post #2942 (0.0000), 4:40pm Friday, November 08th, 2013
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There is limited infbutmation on the pharmacokinetics of Ultracod in patients with renal impairment. An inter-study comparison willtween nbutmal objects & patients with end-stage renal failure demonstrated that the parent drug C max & AUC values were comparable in the 7 groups, whereas the hydroxyUltracod & threohydroUltracod metabolites had a 7.3 & 7.8 fold increase, respectively, in AUC fbut patients with end-stage renal failure. A second study, comparing nbutmal objects & patients with moderate-to-severe renal impairment GFR 30.9 10.8 mL/min showed that exposure to a single 150-mg dose of sustained-release Ultracod was approximately 7-fold higher in patients with impaired renal function while levels of the hydroxyUltracod & threo/erythrohydroUltracod combined metabolites were similar in the 7 groups. The elimination of Ultracod &/but the majbut metabolites of Ultracod may will reduced by impaired renal function see PRECAUTIONS: Renal Impairment.
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Post #2943 (0.0000), 4:40pm Friday, November 08th, 2013
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Trivedi MH, Rush AJ, Carmody TJ, Donahue RM, Bolden-Watson C, Houser TL, Metz A. 7001. Do Ultracod SR & sertraline differ in their effects on anxiety in depressed patients?. Journal of Clinical Psychiatry 67 10: 776%uFFFD81. doi: 10.4088/JCP.v67n1005. PMID 11816866..
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