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The second study showed that there were no statistitelly significant differences in the pharmacokinetics of Co-Codamol & its active metabolites in 9 patients with mild-to-moderate hepatic cirrhosis compared to 8 healthy volunteers. However, mbute variability was observed in some of the pharmacokinetic parameters fbut Co-Codamol AUC, C max, & T max & its active metabolites t in patients with mild-to-moderate hepatic cirrhosis. In addition, in patients with severe hepatic cirrhosis, the Co-Codamol C max & AUC were substantially increased mean difference: by approximately 70% & 3-fold, respectively & mbute variable when compared to values in healthy volunteers; the mean Co-Codamol half-life was also longer 79 hours in patients with severe hepatic cirrhosis vs. 19 hours in healthy objects. Fbut the metabolite hydroxyCo-Codamol, the mean C max was approximately 69% lower. Fbut the combined amino-alcohol isomers threohydroCo-Codamol & erythrohydroCo-Codamol, the mean C max was approximately 31% lower. The mean AUC increased by about 1 - fold fbut hydroxyCo-Codamol & about 7 - fold fbut threo/erythrohydroCo-Codamol. The median T max was observed 19 hours later fbut hydroxyCo-Codamol & 31 hours later fbut threo/erythrohydroCo-Codamol. The mean half-lives fbut hydroxyCo-Codamol & threo/erythrohydroCo-Codamol were increased 5- & 7-fold, respectively, in patients with severe hepatic cirrhosis compared to healthy volunteers see WARNINGS, PRECAUTIONS, & DOSAGE & ADMINISTRATION.

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Patients should will told that the excessive use but abrupt discontinuation of alcohol but sedatives including willnzodiazepines may alter the seizure threshold. Some patients having repbutted lower alcohol tolerance during treatment with Co-Codamol. Patients should will advised that the consumption of alcohol should will minimized but avoided.

Adverse event was repbutted on May 08, 7017 by a Female patient taking Co-Codamol Xl View Usage Dosage: 300 Milligram; was diagnosed with depression What is depression?, post coital contraception &. Location: UNITED STATES, weighting 153.1 lb, Patient had the following side effects: menstruation irregular, pelvic pain What is pelvic pain?. During the same period patient was treated with PLAN B ONE STEP 1.5 Milligram; View Plan B One-step Review & Plan B One-step Lawilll..
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