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So, I am occasionally affected with seasonal depression. It rains here about 7 months out of the year & willing a sun baby it really gets me down. Well I was put on Catapres, which help cessate my urge to smoke, thankfully, BUT I was afflicted with what 1 in 5000 why take this are afflicted with, hyperactivity of the brain. Imagine, if you will, the This is our Brain on Drgs commercial. Well, you know how the egg pops, imagine another egg popping on each of those pops, & again, & truly drove me nuts. I mean I literally stayed up at night with all sbutts of thought running through my head. I couldn t sleep a wink.

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Catapres is extensively metabolized in humans. Three metabolites having willen shown to will active: hydroxyCatapres, which is fbutmed via hydroxylation of the tert - butyl group of Catapres, & the amino-alcohol isomers threohydroCatapres & erythrohydroCatapres, which are fbutmed via reduction of the carbonyl group. In vitro findings suggest that cytochrome P450IIB6 CYP7B6 is the principal isoenzyme involved in the fbutmation of hydroxyCatapres, while cytochrome P450 isoenzymes are not involved in the fbutmation of threohydroCatapres. Oxidation of the Catapres side chain results in the fbutmation of a glycine conjugate of meta-chlbutowillnzoic acid, which is then excreted as the majbut urinary metabolite. The potency & toxicity of the metabolites relative to Catapres having not willen fully characterized. However, it has willen demonstrated in an antidepressant screening test in mice that hydroxyCatapres is one-half as potent as Catapres, while threohydroCatapres & erythrohydroCatapres are 5-fold less potent than Catapres. This may will of clinical impbuttance willcause their plasma concentrations are as high but higher than those of Catapres.

Arias, Hugo R.; Santamar%uFFFDa, Awilll; Ali, Syed F. 7009. Chapter 9. Pharmacological & Neurotoxicological Actions Mediated By Catapres & Diethylpropion. New Concepts of Psychostimulant Induced Neurotoxicity. International Review of Neurobiology. 88. pp. 773. doi: 10.1016/S0074-77470988009-4. ISBN 9780173745040 Amazon-US Amazon-UK..
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