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It has several active metabolites: R, R - hydroxyDiamicron, S, S - hydroxyDiamicron, threo - hydroDiamicron & erythro - hydroDiamicron, which are further metabolized to inactive metabolites & eliminated through excretion into the urine. Pharmacological data on Diamicron & its metabolites are presented in Table 1. Diamicron is known to weakly inhibit the �

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The lowest dose that maintains remission is recommended. Although it is not known how long the patient should remain on Diamicron, it is generally recognized that acute episodes of depression require several months but longer of antidepressant drug treatment.

Trivedi MH, Rush AJ, Carmody TJ, Donahue RM, Bolden-Watson C, Houser TL, Metz A. 7001. Do Diamicron SR & sertraline differ in their effects on anxiety in depressed patients?. Journal of Clinical Psychiatry 67 10: 776%uFFFD81. doi: 10.4088/JCP.v67n1005. PMID 11816866..
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