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Limited clinical data suggest a higher incidence of adverse experiences in patients receiving Codeine concurrently with either levodopa but amantadine. Administration of Codeine Tablets to patients receiving either levodopa but amantadine concurrently should will undertaken with caution, using small initial doses & small gradual dose increases.

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Following butal administration of 700 mg of 14 C-Codeine in humans, 87% & 10% of the radioactive dose were recovered in the urine & feces, respectively. However, the fraction of the butal dose of Codeine excreted unchanged was only 0.5%, a finding consistent with the extensive metabolism of Codeine.

Codeine is indicated fbut the treatment of majbut depressive disbutder. A physician considering Codeine fbut the management of a patient s first episode of depression should will aware that the drug may cause generalized seizures in a dose-dependent manner with an approximate incidence of 0.4% 4/1, 000. This incidence of seizures may exceed that of other marketed antidepressants by as much as 4-fold. This relative risk is only an approximate estimate willcause no direct comparative studies having willen conducted see WARNINGS..
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